Circulating Interferon Induced by Newcastle Disease Virus

Circulating interferon production, induced by Newcastle disease virus, is about seven times higher in C57 Black mice than in Balb/c/Gif mice. A Mendelian analysis was carried out and circulating interferon production was measured in reciprocal F1 hybrids, in the F2 generation, in progeny of backcrosses of F1 hybrids to either parent strain, and in second backcross progeny. The results indicate that a single, partly dominant, autosomal factor is responsible for the difference in circulating interferon production between both parent strains.